PtdIns-(3,4,5)-P3(1-硬脂酰基,2-花生四烯酰基)(钠盐)
基本信息
产品名称 | PtdIns-(3,4,5)-P3(1-硬脂酰基,2-花生四烯酰基)(钠盐) |
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英文名称 | PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt) |
别名 | Phosphatidylinositol-3,4,5-triphosphate C-18 (sodium salt) |
英文别名 | Phosphatidylinositol-3,4,5-triphosphate C-18 (sodium salt) |
运输条件 | 超低温冰袋运输 |
一般描述
磷脂酰肌醇(PtdIns)磷酸占总膜磷脂的一小部分,但它们在细胞信号的产生和传输中起着至关重要的作用.PtdIns-(3,4,5)-P3可以作为锚定带有普列克斯特林同源性(PH)域的信号转导蛋白。半人马苷α和Akts是PtdIns-(3,4,5)-P3结合蛋白的例子。蛋白与PtdIns-(3,4,5)-P3的结合对于细胞骨架重排和膜运输非常重要。PtdIns-(3,4,5)-P3可以抵抗PI特定PLC的切割。因此,它有可能在信号转导中本身起调节剂的作用,而不是作为肌醇四磷酸酯的来源。
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals.PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.
相关属性
储存温度 | -20°C储存 |
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分子量 | 1215 |
分子式 | C₄₇H₈₂O₂₂P₄・4Na |
品牌 | Jinpan |
Smiles | CCCCCCCCCCCCCCCCCC(OCC(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COP([O-])(O[C@@H]1[C@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@ |