PtdIns-（1,2-二辛酰基）（钠盐）

磷脂酰肌醇（PtdIns）磷酸酯占总膜磷脂的一小部分，但它们在细胞信号的产生和传递中起着至关重要的作用。PtdIns-（1,2-二辛酰基）是天然PtdIns的合成类似物，其在sn-1和sn-2位置包含饱和C8：0脂肪酸。该化合物包含与天然化合物相同的肌醇和二酰基甘油（DAG）立体化学。与天然存在的PtdIns相比，该类似物的短脂肪酸链为其赋予了不同的物理特性，包括在水性介质中的高溶解度。PtdIns被磷酸化为单磷酸（PtdIns-P; PIP），二磷酸（PtdIns-P2; PIP2）和三磷酸酯（PtdI

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural PtdIns containing saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound contains the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog, in contrast to naturally-occurring PtdIns, gives it different physical properties including high solubility in aqueous media. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.