丙戊酸β-D-葡糖醛酸

丙戊酸β-D-葡萄糖醛酸是丙戊酸的代谢产物。丙戊酸是一种支链脂肪酸，据报道可以潜在地增强中枢GABA能神经传递并抑制Na | + |通道。目前，尚未完全阐明丙戊酸的各种分子作用机理。据报道，丙戊酸在体外是组蛋白脱乙酰基酶（HDACs）的有效抑制剂。还注意到丙戊酸可减轻HDAC依赖的转录抑制，并在培养的细胞中引起组蛋白的超乙酰化。此外，据报道，丙戊酸在抑制组蛋白脱乙酰基酶中可以激活Wnt依赖性基因表达并模仿曲古抑菌素A。|丙戊酸的代谢产物还可以通过以下方式获得：|丙戊酸|丙戊酸酸，钠盐| 3-羟基丙戊酸|

Valproic Acid β-D-Glucuronide is a metabolite of Valproic Acid. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na|+|channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs)|in vitro|. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase.|Metabolites of Valproic Acid are also available as:|Valproic Acid |Valproic Acid, Sodium Salt |3-Hydroxy Valproic Acid |3-Keto Valproic Acid Sodium Salt |4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) |rac 5-Hydroxy Valproic Acid Sodium Salt |Valproic Acid β-D-Glucuronide Allyl Ester |Labelled forms of Valproic Acid are available as:|Valproic Acid-d6 |Valproic Acid-d6 β-D-Glucuronide |rac 5-Hydroxy Valproic Acid-d7 Sodium Salt