3′-叠氮基3′-脱氧胸苷β-D-葡萄糖醛酸钠盐

3′-叠氮基3′-脱氧胸苷β-D-葡糖醛酸钠盐是葡糖醛酸的代谢产物，它通过抑制逆转录酶而作为HIV-1复制的选择性抑制剂。研究表明依法韦伦可以抑制3′-叠氮基3′-脱氧胸苷形成3′-叠氮基3′-脱氧胸苷β-D-葡萄糖醛酸钠盐。替代研究表明，可以将3′-叠氮基3′-脱氧胸苷β-D-葡糖苷酸钠盐用作血浆和细胞标志物，以确定接受NRTIs的脐带血单核细胞中的DNA损伤。已知3′-叠氮基-3′-脱氧胸苷β-D-葡糖醛酸苷钠盐的叠氮基经常被人肝微粒体还原形成氨基衍生物。

3′-Azido-3′-deoxythymidine β-D-glucuronide sodium salt is a metabolite of glucuronide which functions as a selective inhibitor of HIV-1 replication via suppression of reverse transcriptase. Studies indicate that Efavirenz can inhibit the formation of 3′-Azido-3′-deoxythymidine β-D-glucuronide sodium salt from 3′-Azido-3′-deoxythymidine . Alternate studies demonstrate that 3′-Azido-3′-deoxythymidine β-D-glucuronide sodium salt can be used as plasma and cellular markers to determine DNA damage in cord blood mononuclear cells that have received NRTIs. It is known that the azido group of 3′-Azido-3′-deoxythymidine β-D-glucuronide sodium salt regularly undergoes reduction to form the amino derivative by human liver microsomes.