D-myo-Inositol-4-phosphate (ammonium salt)

D-myo-Inositol-4-phosphate (Ins(4)P1)是磷酸肌醇（InsP）分子家族的成员，在细胞信号的传输中作为小的，可溶的第二信使发挥着关键作用。1,2Ins （1,4,5）P3是由磷脂酶C（PLC）介导的磷脂酰肌醇-4,5-二磷酸水解产生的第二种信使，也是对InsP研究最多的信使。Ins（1,4,5）P3与其在内质网上的受体的结合导致钙通道的开放和细胞内钙的增加。Ins（4）P1可以通过肌醇多磷酸1-磷酸酶对Ins（1,4）P2进行磷酸化来形成，也可以通过肌醇单磷酸酶被磷酸化为肌醇来形成。

D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that plays a critical roles as small, soluble second messengers in the transmission of cellular signals.1,2 Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate, and is the most studied of the InsP. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in the opening of calcium channels and an increase in intracellular calcium. Ins(4)P1 can be formed by dephosphorylation of Ins(1,4)P2 by inositol polyphosphate 1-phosphatase or dephosphorylated to inositol by inositol monophosphatase.