2,6-二-O-甲基-β-环糊精
基本信息
产品名称 | 2,6-二-O-甲基-β-环糊精 |
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英文名称 | 2,6-Di-O-methyl-β-cyclodextrin |
别名 | 2,6-二-O-甲基-β-环糊精;二甲基 β-环糊精 ;七(2,6-二-O-甲基)-β-环糊精;DM‐β‐CyD;DM-β-CD;七-(2,6-O-二甲基)-β-环糊精 |
英文别名 | Heptakis(2,6-di-O-methyl)-β-cyclodextrin;Dimethyl β-cyclodextrin;Dimethyl-beta-cyclodextrin;methylated beta-cyclodextrins |
应用 | 复合物比相应的 β-环糊精复合物具有更高的水溶性;刺激脂肪酸的合成 |
规格或纯度 | 98% |
运输条件 | 常规运输 |
一般描述
水中溶解度: 800 g/L (25°C) ,溶于甲醇、乙醇、丙酮、吡啶、DMSO、和THF。本品属甲基-β-环糊精(2,6-二-O-甲基-,部分的2,3,6-三-O-甲基-混合物)
复合物比相应的 β-环糊精复合物具有更高的水溶性;刺激脂肪酸的合成
Reactant involved in:
• Physicochemical studies of inclusion complexes
• Probing diffusion and single molecule interactions with reconstituted membrane proteins
• Interactions with micelles causing micellar rupture
• Studying cellular transport, used as a cell penetration enhancer
• Physicochemical and biopharmaceutical improvement of drugs particularly with solubilization and stability
• Interactions with cholesterol
Heptakis(2,6-di-O-methyl)-β-cyclodextrin may be used:
• To measure the equilibrium constant of its complexes with various enantiomeric pairs of chiral nitroxides by electron paramagnetic resonance (EPR) spectroscopy.
• To study the crystal structure of its complex with n-butyl acrylate and isobornyl acrylate using X-ray diffraction (XRD).
• As a chiral selector to resolve amphetamine related drugs by capillary zone electrophoresis.
Solubility in water: 800 g / L (25 ° C), dissolved in methanol, ethanol, acetone, pyridine, DMSO, and THF.
Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a hydrophilic derivative of cyclodextrin that possesses the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be utilized to increase the dissolution and bioavailability of weakly water-soluble pharmaceutical compounds.
Complexes are more soluble in aqueous solution than the corresponding complexes of β-cyclodextrin; Stimulation of fatty acid synthesis
Reactant involved in:
• Physicochemical studies of inclusion complexes
• Probing diffusion and single molecule interactions with reconstituted membrane proteins
• Interactions with micelles causing micellar rupture
• Studying cellular transport, used as a cell penetration enhancer
• Physicochemical and biopharmaceutical improvement of drugs particularly with solubilization and stability
• Interactions with cholesterol
Heptakis(2,6-di-O-methyl)-β-cyclodextrin may be used:
• To measure the equilibrium constant of its complexes with various enantiomeric pairs of chiral nitroxides by electron paramagnetic resonance (EPR) spectroscopy.
• To study the crystal structure of its complex with n-butyl acrylate and isobornyl acrylate using X-ray diffraction (XRD).
• As a chiral selector to resolve amphetamine related drugs by capillary zone electrophoresis.
相关属性
CAS编号 | 51166-71-3 |
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熔点 | 180-182°C |
储存温度 | 室温 |
MDL号 | MFCD00011616 |
密度 | 1.4 |
分子量 | 1331.36 |
分子式 | C56H98O35 |
品牌 | Jinpan |
Smiles | COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COC)O[C@H](O[C@@H]4[C@@H](COC)O[C@H](O[C@@H]5[C@@H](COC)O[C@H](O[C@@H]6[C@@H](COC)O[C@H](O[C@@H]7[C@@H](COC)O[C@H](O[C@@H]8[C@@H](COC)O[C@H](O[C@H]1[C@H](O)[C@H]2OC)[C@H](OC)[C@H]8O)[C@H](OC)[C@H]7O)[C@H](OC)[C@H]6O)[C@H](O |
PubChem CID | 10171019 |