2-脱氧-D-葡萄糖
不可代谢的葡萄糖类似物和糖酵解抑制剂。抗肿瘤剂。
98%
有货
基本信息
| 产品名称 | 2-脱氧-D-葡萄糖 |
|---|---|
| 英文名称 | 2-Deoxy-D-glucose |
| 别名 | 2-去氧-D-葡萄糖 |
| 英文别名 | 2-Deoxy-D-arabinohexose;2-Deoxyglucose |
| 应用 | 2-脱氧-D-葡萄糖（2-Deoxy-D-Glucose，2-DG）为天然抗代谢物类抗生素，具有能够抑制病毒感染、酵母发酵、致病菌及肿瘤细胞生长等。 |
| 规格或纯度 | 98% |
| 运输条件 | 冰袋运输 |
| 生化机理 | 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.Non-metabolizable glucose analog and glycolytic inhibitor. Competitive phosphoglucose isomerase inhibitor. Induces ROS-dependent autophagy (EC 50 = 100 μM) and depletes cellular ATP. Antitumor and antiproliferative activity in vivo and in vitro. Orally ac |
一般描述
溶于水和乙醇。2-脱氧-D-葡萄糖（2-Deoxy-D-Glucose，2-DG）为天然抗代谢物类抗生素，具有能够抑制病毒感染、酵母发酵、致病菌及肿瘤细胞生长等。
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
相关属性
| CAS编号 | 154-17-6 |
|---|---|
| 比旋光度 | 46.5 ° (C=1, H2O) |
| 熔点 | 146-147°C |
| 溶解性 | Soluble in water. |
| 储存温度 | 2-8°C储存 |
| Reaxys-RN | 1723331 |
| RTECS | MQ3325000 |
| MDL号 | MFCD00151328 |
| 密度 | 1.533 |
| 分子量 | 164.16 |
| 分子式 | C6H12O5 |
| EC号 | 205-823-0 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 108223 |