PtdIns-（4,5）-P2（1,2-二苯甲酰基）-d62（钠盐）

在2、2’，3、3’，4、4’，5、5’，6、6’，7、7’，8、8’，9、9’，10、10’处包含62个氘原子每个脂肪酰基链的、、 11、11’，12、12’，13、13’，14、14’，15、15’，16、16和16位，用作定量的内标GC-或LC-质谱法测定PtdIns-（4,5）-P2（1,2-二棕榈酰基）（钠盐）磷脂酰肌醇（PtdIns）磷酸酯占总膜磷脂的一小部分，但它们在细胞信号的产生和传递中起着至关重要的作用。PtdIns-4,5-P2-（1,2-二棕榈酰）-d62是天然PtdIns的合成类似

Contains 62 deuterium atoms at the 2, 2′, 3, 3′, 4, 4′, 5, 5′, 6, 6′, 7, 7′, 8, 8′, 9, 9′, 10, 10′, 11, 11′, 12, 12′, 13, 13′, 14, 14′, 15, 15′, 16, 16, and 16 positions of each fatty acyl chain and is intended for use as an internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry. The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-4,5-P2-(1,2-dipalmitoyl)-d62 is a synthetic analog of natural PtdIns featuring deuterated C16:0 fatty acids at sn-1 and sn-2 positions. This synthetic standard contains the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of phosphatidylinositol 4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.