蔗糖八硫酸钠盐

蔗糖八硫酸钠盐（SOS）是胃肠保护剂硫糖铝的成分，是一种碱性铝-蔗糖复合物，可抑制消化性水解并提高胃的pH值，从而保护食道上皮免遭酸损伤。蔗糖八硫酸钠钠盐可与凝血酶的外位II结合并抑制其催化活性，因此已被用作肝素的替代物。此外，已显示蔗糖八硫酸钠钠盐可通过防止成纤维细胞生长因子2（FGF-2）与内皮细胞结合并从这些细胞中去除任何预结合的FGF-2来抑制小鼠黑素瘤和肺癌模型中的肿瘤生长。蔗糖八硫酸钠钠盐也称为硫糖酯钾，SOS，2,3,4,6-四（硫酸氢盐），1,3,4,6-四-O-磺基-β-D-果糖呋喃糖基

Sucrose octasulfate sodium salt (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum?sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. Sucrose octasulfate sodium salt can bind to exosite II of thrombin and inhibit its catalytic activity and, as such, has been used as a surrogate for heparin. Furthermore, Sucrose octasulfate sodium salt has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells. Sucrose octasulfate sodium salt is also known as Sucrosofate potassium, SOS, 2,3,4,6-tetrakis(hydrogen sulfate),1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl α-D-glucopyranoside, octapotassium and 1,3,4,6-Tetra-O-sulfo-b-D-fructofuranosyl-2,3,4,6-tetrakis(hydrogen sulfate)-a-D-glucopyranoside sodium salt.