异硫氰酸荧光素-葡聚糖

应用

FITC-葡聚糖在心血管、微循环、灌注、细胞单层和细胞膜通透性研究中用作荧光通量示踪化合物，可实现对血流、膜损伤、血管引流和肾脏清除等过程进行检测。 小FITC-葡聚糖也可用于检测内吞作用和细胞连接通透性等过程。FITC-葡聚糖70 kDa（FD-70）可用作模型化合物，用于开发将分子递送到原生质体中和研究从水凝胶和脂质体等结构释放药物的方法。FD-70可用于微血管和细胞单层的通透性研究。 用异硫氰酸荧光素标记的葡聚糖可用于动物的灌注研究。

Application

FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. Small FITC-dextrans are also used to measure processes such as endocytosis and cell junction permeability. FITC-dextran 70 kDa (FD-70) may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. FD-70 may be used in microvascular and cell monolayer permeability studies. Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.