阿法拉定A，TFA
基本信息
| 产品名称 | 阿法拉定A，TFA |
|---|---|
| 英文名称 | Ageladine A, TFA |
| 英文别名 | (4-(4,5-Dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]-pyridin-2-amine), TFA |
| 运输条件 | 冰袋运输 |
一般描述
Ageladine A，TFA是一种pH敏感的荧光染料，由于其无毒性质，可用于在酸性细胞器，细胞和整个动物中进行实时成像，但是在碱性溶液中的检测受到限制。Ageladine A，TFA通过膜内侧的疏水相互作用被捕获在细胞和细胞器中。由于新陈代谢有限，因此具有长期稳定性，这会导致光漂白变慢。Ageladine A，TFA是一种血管生成抑制剂，并且还抑制基质金属蛋白酶MMP-1，-2，-8，-9，-12，-13和激酶Tyk2，Dyrk2，Dyrk1A和Rsk-1。
Ageladine A, TFA is a pH-sensitive fluorescent dye which can be used for live imaging in acidic organelles, cells, and whole animals due to its non-toxic nature, however there is limited detection in alkaline solutions. Ageladine A, TFA is trapped in cells and organelles via hydrophobic interactions on the inner side of membranes. It exhibits long-term stability due to limited metabolization, which causes slow photobleaching. Ageladine A, TFA is an angiogenesis inhibitor, and also inhibits the matrix metalloproteinases MMP-1, -2, -8, -9, -12, -13 and the kinases Tyk2, Dyrk2, Dyrk1A, and Rsk-1.
相关属性
| CAS编号 | 643020-13-7 |
|---|---|
| 折光率 | n20D~1.83 (Predicted) |
| 溶解性 | Soluble in DMSO, and methanol. |
| 储存温度 | 2-8°C储存 |
| 分子量 | 471.03 |
| 分子式 | C10H7Br2N5.CF3CO2H |
| 品牌 | Jinpan |
| Smiles | C1=CN=C(C2=C1NC(=N2)N)C3=CC(=C(N3)Br)Br |
| PubChem CID | 10089677 |
| x_emission | λem 415 nm |
| x_excitation | λex 370 nm |