N，O-二甲基（rac-文拉法辛）盐酸葡萄糖醛酸
基本信息
| 产品名称 | N，O-二甲基（rac-文拉法辛）盐酸葡萄糖醛酸 |
|---|---|
| 英文名称 | N,O-Didesmethyl-(rac-venlafaxine) Glucuronide Hydrochloride |
| 运输条件 | 超低温冰袋运输 |
一般描述
N，O-二甲基-（rac-文拉法辛）葡萄糖苷酸盐酸盐是文拉法辛的代谢产物。文拉法辛是苯乙胺的衍生物，据报道可通过阻止神经胺如5-羟色胺（5-羟色胺； 5-HT）和去甲肾上腺素（去甲肾上腺素）的突触前再摄取来促进中枢神经系统内的神经传递。还报道了文拉法辛是多巴胺再摄取的弱抑制剂。|体外研究表明，文拉法辛对毒蕈碱，组胺能或α-1肾上腺素受体没有明显的活性。据报道，文拉法辛的代谢是通过细胞色素P450（CYP）酶CYP2D6发生的，产生O-去甲基文拉法辛。CYP3A4产生较少的代谢产物N-去甲基文拉法辛。
N,O-Didesmethyl-(rac-venlafaxine) Glucuronide Hydrochloride is a metabolite of Venlafaxine . Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake.|In vitro|studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.
相关属性
| CAS编号 | 1021933-99-2 |
|---|---|
| 熔点 | >150° C (dec.) |
| 溶解性 | Soluble in DMSO, and water. |
| 储存温度 | -20°C储存 |
| 分子量 | 461.93 |
| 分子式 | C₂₁H₃₂ClNO₈ |
| 品牌 | Jinpan |
| Smiles | Cl.CNC[C@H](C1=CC=C(O[C@@H]2OC([C@@H](O)C(O)C2O)C(O)=O)C=C1)C1(O)CCCCC1 |
| PubChem CID | 46781271 |