PtdIns-（3,4,5）-P3（1,2-二棕榈酰）（钠盐）
基本信息
| 产品名称 | PtdIns-（3,4,5）-P3（1,2-二棕榈酰）（钠盐） |
|---|---|
| 英文名称 | PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) |
| 运输条件 | 超低温冰袋运输 |
一般描述
磷脂酰肌醇磷酸酯占总膜磷脂的一小部分，但它们在细胞信号的产生和传递中起着至关重要的作用。PtdIns-（3,4,5）-P3可以充当锚定蛋白，结合带有pleckstrin同源性（PH）域的信号转导蛋白。Centuarinα和GTPase激活蛋白的Akt家族是PtdIns-（3,4,5）-P3结合蛋白的例子。蛋白与PtdIns-（3,4,5）-P3的结合对于细胞骨架重排和膜运输非常重要。PtdIns-（3,4,5）-P3对PI特异性磷脂酶C（PLC）的切割具有抗性。因此，它有可能在信号转导中本身起调节剂的作用
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.
相关属性
| 折光率 | n20D1.53 (Predicted) |
|---|---|
| 溶解性 | Soluble in PBS (pH 7.2) (~10 mg/ml). Sparingly soluble in organic solvents such as ethanol, DMSO, and DMF. |
| 储存温度 | -20°C储存 |
| 分子量 | 1138.91 |
| 分子式 | C₄₁H₇₈O₂₂P₄₄Na |
| 品牌 | Jinpan |
| Smiles | [O-]P(OCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)(O[C@@H]1[C@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O)=O |
| Ki Data | RAC-alpha serine/threonine-protein kinase: Ki= 0.5 µM (mouse) |