1-十八烷基溶血磷脂酸（钠盐）

1-十八烷基溶血磷脂酸（钠盐）是LPA类似物，在sn-1位置含有硬脂醇。LPA与五种不同的G蛋白连锁受体之一结合，以介导多种生物学反应，包括细胞增殖，平滑肌收缩，血小板聚集，神经突收缩和细胞运动。烷基醚连接的LPA衍生物比酰基衍生物具有更高的血小板聚集活性，这很可能源于烷基特异性LPA受体。例如，1-十八烷基LPA具有的血小板聚集活性，EC1值为9 nM，而1-十八烷基LPA的EC50值为177 nM。

1-Octadecyl Lysophosphatidic Acid (sodium salt) is an LPA analog that contains stearyl alcohol at the sn-1 position. LPA binds to one of five different G protein-linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.
1-Octadecyl Lysophosphatidic Acid (sodium salt)is binds to one of five different G protein-linked receptors to mediate a variety of biological responses