Anti-Human Granulysin PE

货　　号：12-8828-42

产品规格：100 tests

原  产  地：USA

参考价格：3108 （参考价格，以实际价格为准）

优惠价格：

Anti-Human Granulysin PE   12-8828-42

Host     Mouse
Isotype     IgG1, kappa
Reactivity     Human
Conjugate     PE
Laser     Blue Laser, Green Laser, Yellow-Green Laser
Emit     575 nm
Excite     488 – 561 nm
Reported Applications     Intracellular Staining Followed by Flow Cytometric Analysis, Immunohistochemical Staining of Frozen Tissue Sections

References: Tilburgs T, Schonkeren D, Eikmans M, Nagtzaam NM, Datema G, Swings GM, Prins F, van Lith JM, van der Mast BJ, Roelen DL, Scherjon SA, Claas FH. Human Decidual Tissue Contains Differentiated CD8+ Effector-Memory T Cells with Unique Properties. J Immunol. 2010 Sep 3. (eBioDH2, FC, PubMed)

Gansert JL, Kiessler V, Engele M, Wittke F, Rollinghoff M, Krensky AM, Porcelli SA, Modlin RL, Stenger S. Human NKT cells express granulysin and exhibit antimycobacterial activity. J Immunol. 2003 Mar 15;170(6):3154-61.

Hanson DA, Kaspar AA, Poulain FR, Krensky AM. Biosynthesis of granulysin, a novel cytolytic molecule. Mol Immunol. 1999 May;36(7):413-22.

Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL.T-cell release of granulysin contributes to host defense in leprosy.Nat Med. 2001 Feb;7(2):174-9.

Stegelmann F, Bastian M, Swoboda K, Bhat R, Kiessler V, Krensky AM, Roellinghoff M, Modlin RL, Stenger S. Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis.J Immunol. 2005 Dec 1;175(11):7474-83.

Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL.An antimicrobial activity of cytolytic T cells mediated by granulysin.Science. 1998 Oct 2;282(5386):121-5.

Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 2;282(5386):121-5.

Anti-Human IL-23 p19 PE

货　　号：12-7823-41

产品规格：25 tests

原  产  地：USA

参考价格：1668 （参考价格，以实际价格为准）

优惠价格：

Anti-Human IL-23 p19 PE   12-7823-41

Host     Mouse
Isotype     IgG2b, kappa
Reactivity     Human
Conjugate     PE
Laser     Blue Laser, Green Laser, Yellow-Green Laser
Excite     488 – 561 nm
Reported Applications     Flow Cytometric Analysis

References: Kalim KW, Groettrup M. Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. Mol Immunol. 2013 Mar;53(3):274-82 (23dcdp, FC, PubMed)

Brentano F, Ospelt C, Stanczyk J, Gay RE, Gay S, Kyburz D. Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in the rheumatoid arthritis. Ann Rheum Dis. 2009 Jan; 68(1): 143-50.\\ Dennehy KM, Willment JA, Williams DL, Brown GD. Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways. Eur J Immunol. 2009 May;39(5): 1379-86\\Hillyen P, Larche MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM. Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis. Rheumatology. 2009; 48: 1581-9\\Goriely S., Neurath MF., and Goldman M. How microorganisms tip the balance between interleukin-12 family members. Nat Rev Immunol. 2008 Jan;8(1):81-6