3-PT-PtdIns（3,4,5）-P3（1,2-二辛酰基），钠盐

3-PT-PtdIns（3,4,5）-P 3（1,2-二辛酰基）钠盐（3-PT-PtdIns（3,4,5）-P3）是PtdIns-（ 3,4,5）-P3耐PTEN水解。它对特定的PtdIns（3,4,5）-P3结合蛋白GRP1的亲和力降低了5倍，并增加了A6细胞单层中的钠转运。磷脂酰肌醇（PtdIns）磷酸酯占总膜磷脂的一小部分。然而，它们在蜂窝信号的产生和传输中起关键作用。PtdIns（4,5）-P2可以被磷酸肌醇（PI）-3-激酶磷酸化，从而生成PtdIns（3,4,5）-P3，该PtdIns（3,4

3-PT-PtdIns (3,4,5)-P|3|(1,2-dioctanoyl), sodium salt (3-PT-PtdIns(3,4,5)-P3) is an analog of PtdIns-(3,4,5)-P3 that is resistant to hydrolysis by PTEN. It has a 5-fold reduced affinity for specific PtdIns(3,4,5)-P3-binding protein GRP1 and increases sodium transport in A6 cell monolayers. Phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in generation and transmission of cellular signals. PtdIns(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer.
3-PT-PtdIns (3,4,5)-P3(1,2-dioctanoyl), sodium saltis an analog of PtdIns-(3,4,5)-P3 with reduced affinity for PtdIns-(3,4,5)-P3 binding protein GRP1