PtdIns-（3）-P1（1,2-二棕榈酰）（铵盐）

磷脂酰肌醇磷酸酯在总膜磷脂中所占的比例很小，但它们在细胞信号的产生和传输中起着至关重要的作用。1,2PtdIns-（3）-P1可以进一步被磷酸化，得到三磷酸酯

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids but they play a crucial role in the generation and transmission of cellular signals.1,2 PtdIns-(3)-P1 can be further phosphorylated to give triphosphates such

PtdIns-（3,4,5）-P3（1,2-二己酰基）（铵盐）

磷脂酰肌醇（PtdIns）磷酸酯占总膜磷脂的一小部分，但它们在细胞信号的产生和传递中起着至关重要的作用。PtdIns-（3,4,5）-P3，也称为PIP3，对PI特异性磷脂酶C（PLC）的切割具有抗性。因此，它很可能本身就可以作为信号调节剂而不是肌醇四磷酸酯的来源发挥作用​​。PIP3可以充当锚定信号蛋白的信号蛋白的结合锚点（普列克底物蛋白同源性）域。蛋白质与PIP3的结合对于细胞骨架重排和膜运输非常重要。PtdIns-（3,4,5）-P3（1,2-二己酰基）是天然PIP3的合成类似物，在sn-1和sn-

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, instead of a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with saturated C6 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)is a synthetic analog of PIP3

PtdIns-（3,4,5）-P3（1,2-二棕榈酰）（钠盐）

磷脂酰肌醇磷酸酯占总膜磷脂的一小部分，但它们在细胞信号的产生和传递中起着至关重要的作用。PtdIns-（3,4,5）-P3可以充当锚定蛋白，结合带有pleckstrin同源性（PH）域的信号转导蛋白。Centuarinα和GTPase激活蛋白的Akt家族是PtdIns-（3,4,5）-P3结合蛋白的例子。蛋白与PtdIns-（3,4,5）-P3的结合对于细胞骨架重排和膜运输非常重要。PtdIns-（3,4,5）-P3对PI特异性磷脂酶C（PLC）的切割具有抗性。因此，它有可能在信号转导中本身起调节剂的作用

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.

PtdIns-（3,4,5）-P3（1-硬脂酰基，2-花生四烯酰基）（钠盐）

磷脂酰肌醇（PtdIns）磷酸占总膜磷脂的一小部分，但它们在细胞信号的产生和传输中起着至关重要的作用.PtdIns-（3,4,5）-P3可以作为锚定带有普列克斯特林同源性（PH）域的信号转导蛋白。半人马苷α和Akts是PtdIns-（3,4,5）-P3结合蛋白的例子。蛋白与PtdIns-（3,4,5）-P3的结合对于细胞骨架重排和膜运输非常重要。PtdIns-（3,4,5）-P3可以抵抗PI特定PLC的切割。因此，它有可能在信号转导中本身起调节剂的作用，而不是作为肌醇四磷酸酯的来源。

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals.PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.